And this concentration in molars may be a biomarker of perinatal exposure and during molar formation. There is an urgent need for accurate information on the problems associated with exposure to organophosphorus compounds. It would be helpful if the following information is readily available: Type, amount and time of consumption of the substance, And, the overall health status of the individual. The chemical may be absorbed through the skin. [11], Diethoxy-[(2-isopropyl-6-methyl-4-pyrimidinyl)oxy]-thioxophosphorane, InChI=1S/C12H21N2O3PS/c1-6-15-18(19,16-7-2)17-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3, InChI=1/C12H21N2O3PS/c1-6-15-18(19,16-7-2)17-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3, Except where otherwise noted, data are given for materials in their, Learn how and when to remove this template message, National Institute for Occupational Safety and Health, "EPA Takes Pest Killer Diazinon Off the Shelves", http://www.apvma.gov.au/products/review/docs/diazinon_hh_tox_part_2.pdf, Diazinon Technical Fact Sheet - National Pesticide Information Center, Diazinon Pesticide Information Profile - Extension Toxicology Network, CDC - NIOSH Pocket Guide to Chemical Hazards - Diazinon, Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide), 2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate, Muscarinic acetylcholine receptor modulators, Nicotinic acetylcholine receptor modulators, https://en.wikipedia.org/w/index.php?title=Diazinon&oldid=998952942, Articles needing additional references from January 2013, All articles needing additional references, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles with unsourced statements from January 2021, Creative Commons Attribution-ShareAlike License, Irrigation (washing of the skin and eyes), Medicinal Treatments; including the antidotes, Many of the other AChE inhibitors listed above, This page was last edited on 7 January 2021, at 20:10. Someswar, G., Kumar, Y. R. N., Kumari, V. S., Gupta, A. V. G., & Prabhakar, R. R. (2015). Study of serial evaluation of serum cholinesterase level as a prognostic indicator in patients of organophosphorous poisoning. Poisoning can occur if you swallow diazinon. Diazinon poisoning Definition Diazinon is an insecticide, a product used to kill or control bugs. Diazinon is an insecticide that belongs to a group of chemicals known as organophosphates. [5] The chemical is still used for agricultural purposes and those cattle ear tags designed to contain chemicals to control insects. Symptoma. Several systems of the body, such as the digestive system, nervous system, vascular system, respiratory system, skin and ENT may be affected. The removal of organophosphates (OPE) from water by adsorption techniques is regarded as one of the competitive methods because of its simple operation and low cost. Poisoning can occur if you swallow diazinon. Forensic science international, 228(1), e20-e24. The compound is also used to protect pets against flea bites, Diazinon Poisoning is the accidental or intentional intake of any product containing the toxic compound, The condition is diagnosed based upon the clinical history, combination of signs and symptoms, and additional tests (that may include, in some cases, radiological studies and laboratory tests), Diazinon Poisoning is caused by the intake or ingestion of diazinon compound. Diazinon can also be decomposed via oxidation in the liver (Reaction 2). The responders will wear protective gear. Diazinon Poisoning or Diazinon Toxicity may be also referred to variously as the following: Note: The compound can interact with other prescribed or non-prescribed medications in the body. These responders will decontaminate the person by removing the person's clothes and washing them down with water. Konickx, L. A., Bingham, K., & Eddleston, M. (2014). Poisoning can occur if you swallow diazinon. PROFILE OF ORGANOPHOSPHORUS POISONING IN SOUTH EAST RAJASTHAN IN MEDICAL COLLEGE HOSPITAL, JHALAWAR, (390). Diazinon has been used in the United States since 1956. Diazinon is an insecticide, a product used to kill or control bugs. Objectives . Swarnalatha, K., Rao, B. S. P., & Sonia, S. S. (2016). [citation needed]. The type and severity of symptoms varies depending on the amount of chemical involved and the nature of the exposure. pesticide exposure and emergency first-aid treatment. Development of new adsorbents with high adsorption capacities is very important for removal of the OPE pollutants in the environment.[9]. Insects lack this hydrolysis step, which allows the toxic substance to accumulate rapidly; the detoxification of diazoxon is processed through the microsomal mixed function oxidase system. a substitute for medical intervention. Cranial nerve palsies and depressed tendon reflexes have also been reported. The EPA found Diazinon highly toxic to birds and banned its use in such areas as golf courses. Poisoning can occur if you swallow diazinon. The substance may also cause symptoms due to skin contact, This intake could be accidental, or in some cases intentional, to bring self-harm, Nausea, vomiting, cramping of stomach/abdomen, Breathing difficulties; absence of breathing, Increased or decreased blood pressure (hypertension or hypotension respectively), Bluish skin (especially lips and fingernails), Salivation, increased tearing of eyes, sweating, Vision abnormalities; dilated pupils, lack of sensitivity to light, If the individual with Diazinon Poisoning is in a coma, or is experiencing life-threatening symptoms, call 911 (or your local emergency help number) immediately, Call the Poison Control Center at 1-800-222-1222 (or your local poison control center) for further instructions, Provide them with information such as the compound taken, quantity and time of ingestion, age, weight and general health status of affected individual, Confirm that the airways are protected; also, ensure breathing and the presence of pulse, If skin or eye exposure has occurred, then wash thoroughly with copious amounts of water, Take individual to emergency room (ER) for further treatment, Always try to take the product bottle/container to the ER, Dispose contaminated clothing, while wearing protective gloves/gear, based on suitable instruction of poison control center, Decontaminate the individual before starting treatment (usually done by the first responders), If necessary, gastric lavage for elimination of substance from the stomach (irrigation using special solutions), Administer suitable medication to counter effects of the toxin, Medically manage symptoms, such as abnormal heart rate and seizures, Wash skin and eyes repeatedly and thoroughly (irrigation), to eliminate any remaining hazardous compound, Administer laxatives for elimination of the substance from the body, Administer fluids by an intravenous drip line, The individual who is affected, or someone near, should call 911 for emergency assistance (or the local emergency number), They should also call the poison control center at 1-800-222-1222 (or the local poison control center) and follow instructions, The prognosis of Diazinon Poisoning is dependent on the amount of substance consumed, time between consumption and treatment, severity of the symptoms, as well as general health status of the patient, If the individual can recover from the symptoms within a period of 4-6 hours, with appropriate medication and support, the outcome is generally good. A Study of Profile of Patients with Organophosphorus Compound Poisoning at a Teaching Hospital. These responders will decontaminate the person by removing the person's clothes and washing them down with water. [citation needed], To date, several methods such as electrochemistry, adsorption, enzymatic biodegradation, and photocatalysis have been tested for the elimination of diazinon from aqueous solutions. Intermediate syndrome generally occurs within 24–96 hours after exposure. International Journal of Basic & Clinical Pharmacology, 5(5), 1937-1941. Molars from the two oldest subjects contained the largest concentrations of IMPy. It is also effective against various pests of fruits, vegetables, tobacco, forage, field crops, range pasture, grasslands and ornamentals. This is for information only and not for use in the treatment or management of an actual poison exposure. Human poisoning victims have shown increased levels of serum amylase and glucose as well as elevated urinary diastase levels accompanied by symptoms considered to be indicative of acute pancreatitis. In CLINICAL TOXICOLOGY (Vol. In general, toxicities are common situations in the emergency departments. This is for information only and not for use in the treatment or management of an actual poison exposure. The responders will wear protective gear. The objectives of this program are to provide workers exposed . Mammals metabolize diazoxon with a half-life of 2 to 6 weeks. After the hydrolysis or oxidation diazinon is broken down further (Reaction 4). Diazinon poisoning Bazinon poisoning; Diazol poisoning; Gardentox poisoning; Knox-Out poisoning; Spectracide poisoning . A report on 100 cases with particular reference to evaluation of treatment. The most commonly used organic phosphorus compounds are diazinon, malathion, and parathion. 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